OTRIVIN SOURCES AND REFERENCES

1 Eccles 2008
2 Naclerio 2007 p4a, Eccles 2003 p275a and 276a
3 Eccles 2005 p718a
4 Naclerio 2010 p48a
5 Fokkens 2012 p5a
6 Grief 2005 p758a
7 Eccles 2009 p23a
8 Eccles 2009 p25a, Grief 2005 p758b, Grief 2009 p890a
9 Mayo clinic 2015
10 Eccles 2009b p255a
11 Mayo clinic 2015
12 Mayo clinic 2015
13 Eccles 2008 and OTR GDS
14 Eccles 2009 p25b
15
http://www.mayoclinic.org/diseases-conditions/flu/expert-answers/flu-symptoms/faq-20057983 (accessed 8 May 2019)
16 Mayo clinic 2015
17 Eccles 2009b p255a
18 Mayo clinic 2015
19 Cleveland clinic 2015 and
http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
20 Eccles 2009 p33a
21 Fokkens 2012 p5a, Grief 2005 p760a
22 Eccles 2009 p33b, Fokkens 2012 p37a, p209a

23 http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
24 http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
25 http://www.otrivine.co.uk/symptoms/allergy (accessed 8 May 2019)
26 Naclerio 2010 p48a
27 Corey 2000 p698a, p700
28 Eccles 2008 p493a, 494a, Eccles 2009 p255a, p255b

29 http://symptoms.webmd.com/cold-flu-map/avoid-cold-flu (accessed 8 May 2019)
30 http://www.health.com/health/gallery/0,,20752945,00.html#sip-tea (accessed 8 May 2019)
31 Grief 2005 p758c and http://www.health.com/health/gallery/0,,20752945,00.html#sanitize-your-office-
space-0
 (accessed 8 May 2019)
32 Grief 2005 p758c
33
http://symptoms.webmd.com/cold-flu-map/avoid-cold-flu (accessed 8 May 2019)
34 Fokkens 2012 p210a, 212a
35 Mayo clinic 2015, Eccles 2009b
36 Mayo clinic 2015
37
https://www.theraflu.com/power-living/lifestyle/should-you-work-out-when-you-are-sick/ (accessed 8 May 2019)
38 http://www.mayoclinic.org/diseases-conditions/hay-fever/in-depth/seasonal-allergies/art-20048343 (accessed 8 May 2019)
39 http://www.webmd.boots.com/allergies/guide/allergy-friendly-outdoor-exercises (accessed 8 May 2019)
40 http://www.webmd.boots.com/allergies/guide/allergy-friendly-outdoor-exercises (accessed 8 May 2019)
41 http://www.webmd.boots.com/allergies/guide/allergy-friendly-outdoor-exercises  (accessed 8 May 2019)
42 http://www.otrivine.co.uk/symptoms/allergy (accessed 8 May 2019)
43 http://www.otrivine.co.uk/symptoms/allergy (accessed 8 May 2019)
44 https://www.flonase.com/allergies/indoor-vs-outdoor-allergens/ (accessed 8 May 2019)
45 Eccles 2008
46 Eccles 2008, OTR GDS
47 GDS
48 GDS
49 GDS
50 GDS
51 GDS
52 GDS
53 GDS
54 GDS
55 GDS
56 GDS
57 Eccles 2008
58 Eccles 2008, GDS
59 GDS
60 GDS

61 Eccles 2008, GDS
62 GDS
63 GDS
64 GDS
65 GDS
66 GDS
67 GDS
68 Wynne 1982 p657a
69 GDS
70 Wynne 1982 p657a
71 Wynne 1982 p657a
72 GDS
73 Eccles 2005 p718a
74 Eccles 2009 p25a, p25c
75 Eccles 2009 p25a
76 Eccles 2009 p25c, p37a
77 Eccles 2009 p37a
78 Eccles 2009 p25b
79 Eccles 2009 p25b
80 Eccles 2005 p718b and 
http://www.otrivine.co.uk/symptoms/cold (accessed 8 May 2019)
81 Eccles 2005 p718a
82 Mayo clinic 2015
83 Mayo clinic 2015
84 Eccles 2009a p25a
85 Eccles 2009b p251a, Mayo clinic 2016
86 Mayo clinic 2015
87 Grief 2005 p758d
88 Grief 2005 p761, 762a
89 Naclerio 2010
90 GDS
91 Fokkens 2012 p5a
92 Eccles 2003 and
http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
93 Cleveland clinic 2015
94 Fokkens 2012 p5a
95 Fokkens 2012 p5a
96 Fokkens 2012 p5a
97 Fokkens 2012 p9a
98 Naclerio 2010 p48b
99 Fokkens 2012 p10a
100
http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
101 Mayo clinic 2015
102
http://symptoms.webmd.com/cold-flu-map/avoid-cold-flu (accessed 8 May 2019)
103 Fokkens 2012 p5
104 Fokkens 2012 p210a
105 Fokkens 2012 p7a
106 Mayo clinic 2015
107 Fokkens 2012 p209a
108 Fokkens 2012 p7b
109 Fokkens 2012 p14a
110
http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
111 Fokkens 2012 p14a
112
http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
113 Naclerio 2010 p50a
114 Fokkens 2012 p15a
115 Eccles 2005 p718a
116 Eccles 2009 p25a, p25c
117 Eccles 2009 p25a
118 Eccles 2009 p25c, p37a
119 Eccles 2009 37a
120 Eccles 2009 p25b
121 Eccles 2009 p25b

122 Eccles 2005 p718b and http://www.otrivine.co.uk/symptoms/cold  (accessed 8 May 2019)
123 Mayo clinic 2015
124 Grief 2005 p758d
125 Mayo clinic 2015
126 Eccles 2009 p25a
127 Eccles 2009 p251a
128 Mayo clinic 2015
129 Naclerio 2010
130
https://www.flonase.com/allergies/indoor-vs-outdoor-allergens/ (accessed 8 May 2019)
131 Eccles 2009 p33a
132
http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
133 Cleveland clinic 2015
134 Eccles 2009 p33a

135 http://www.otrivine.co.uk/symptoms/sinuses (accessed 8 May 2019)
136 Fokkens 2012 p14a
137 Mayo clinic 2015

138 http://symptoms.webmd.com/cold-flu-map/avoid-cold-flu (accessed 8 May 2019)
139 See page 6 of 10767240_Otrivin_Detail_Aid_Expanding_260517.pdf
140 Slide 26 of 10767240_Otrivin_Detail_Aid_Expanding_260517.pdf

141 Slide 14,15 of 10767240_Otrivin_Detail_Aid_Expanding_260517.pdf
142 10767240_Otrivin_Detail_Aid_Expanding_260517.pdf + book of nose
143 3-4 of 10767240_Otrivin_Detail_Aid_Expanding_260517.pdf, + book of nose
144 book of nose + pg 3-4 of 10767240_Otrivin_Detail_Aid_Expanding_260517.pdf,
145 Book of nose
146 Book of nose
147 Otrivin website and product overview deck

148 Patient.co.uk Professional Reference. Influenza. [cited 2018 21 February]; Available from: https://patient.info/doctor/influenza (accessed 8 May 2019)
149 Medscape. Influenza Clinical Presentation. [cited 2018 21 February]; Available from: https://emedicine.medscape.com/article/219557-clinical#showall (accessed 8 May 2019)
150 Medscape. Viral Gastroenteritis. [cited 2018 21 February]; Available from: https://emedicine.medscape.com/article/176515-overview#showall (accessed 8 May 2019)
151 Medscape. Rhinovirus (RV) Infection (Common Cold). [cited 2018 21 February]; Available from: https://emedicine.medscape.com/article/227820-overview#showall (accessed 8 May 2019).
152 NICE Clinical Knowledge Summaries. Common cold. Prognosis. [cited 2018 21 February]; Available from: https://cks.nice.org.uk/common-cold#!backgroundsub:5 (accessed 8 May 2019).
153 Simancas-Racines D Guerra CV Hidalgo R, Vaccines for the common cold. Cochrane Database of Systematic Reviews, 2013.
154 Centers for Disease Control and Prevention. Misconceptions about Seasonal Flu and Flu Vaccines. [cited 2018 21 February]; Available from: https://www.cdc.gov/flu/about/qa/misconceptions.html (accessed 8 May 2019).
155 NICE Clinical Knowledge Summaries. Common cold. Scenario: Management. [cited 2018 21 February]; Available from: https://cks.nice.org.uk/common-cold#!scenario (accessed 8 May 2019).
156 NICE British National Formulary. Nose. [cited 2018 21 February]; Available from: https://bnf.nice.org.uk/treatment-summary/nose.html (accessed 8 May 2019).
157 Centers for Disease Control and Prevention. Common Colds: Protect Yourself and Others. [cited 2018 21 February]; Available from: https://www.cdc.gov/features/rhinoviruses/ (accessed 8 May 2019).
158 Patient.co.uk Professional Reference. Common Cold. [cited 2018 21 February]; Available from: https://patient.info/doctor/common-cold-coryza (accessed 8 May 2019).
159 JaakkolaK et al., Decline in temperature and humidity increases the occurrence of influenza in cold climate. Environ Health, 2014. 13(1): p. 22.
160 British Society for Allergy & Clinical Immunology. Frequently asked questions. [cited 2018 21 February]; Available from:
http://www.bsaci.org/resources/faq (accessed 8 May 2019).
161 World Allergy Organization. IgE in Clinical Allergy and Allergy Diagnosis. [cited 2018 21 February]; Available from: http://www.worldallergy.org/professional/allergic_diseases_center/ige/ (accessed 8 May 2019).
162 Patient.co.uk Professional Reference. Allergic Phenomena [cited 2018 21 February]; Available from: https://patient.info/doctor/allergic-phenomena (accessed 8 May 2019).
163 European Academy of Allergy and Clinical Immunology. Allergen Immunotherapy Guidelines. [cited 2018 21 February]; Available from: www.eaaci.org/documents/AIT_Guidelines-web_version.pdf (accessed 8 May 2019).
164 Patient.co.uk Professional Reference. Asthma [cited 2018 21 February]; Available from: https://patient.info/doctor/asthma-pro (accessed 8 May 2019).
165 Medscape. Allergic and Environmental Asthma Overview of Asthma. [cited 2018 21 February]; Available from: https://emedicine.medscape.com/article/137501-overview#showall (accessed 8 May 2019).
166 Asthma UK. Hay fever treatments. [cited 2018 21 February]; Available from: https://www.asthma.org.uk/advice/inhalers-medicines-treatments/other/hay-fever/ (accessed 8 May 2019).
167 WebMD. Allergy Shots: What to Know. [cited 2018 22 February]; Available from: https://www.webmd.com/allergies/allergy-shots#1 (accessed 8 May 2019).
168 Medscape. Immunotherapy for Allergies Periprocedural Care. [cited 2018 22 February]; Available from: https://emedicine.medscape.com/article/1588289-periprocedure#showall (accessed 8 May 2019).
169 American College of Allergy, A.I. Allergic Rhinitis. [cited 2018 22 February]; Available from: http://acaai.org/allergies/types/hay-fever-rhinitis (accessed 8 May 2019).
170 Patient.co.uk Professional Reference. Food Allergy and Food Intolerance. [cited 2018 22 February]; Available from: https://patient.info/doctor/food-allergy-and-food-intolerance (accessed 8 May 2019).
171 European Academy of Allergy and Clinical Immunology. Allergens and triggers. Contact allergans. [cited 2018 22 February]; Available from: http://www.eaaci.org/patients/allergic-and-immunologic-diseases-and-causes/allergens-and-triggers/contact-allergens.html (accessed 8 May 2019).
172 American Academy of Allergy, A.I. Can spices cause allergic reactions? [cited 2018 22 February]; Available from: https://www.aaaai.org/conditions-and-treatments/library/allergy-library/spice-allergy (accessed 8 May 2019).
173 US National Library of Medicine. Allergies - overview. [cited 2018 22 February]; Available from: https://medlineplus.gov/ency/article/000812.html (accessed 8 May 2019).
174 British Association of Dermatologists. Urticaria and angioedema. [cited 2018 22 February]; Available from: http://www.bad.org.uk/shared/get-file.ashx?id=184&itemtype=document (accessed 8 May 2019).
175 American College of Allergy, A.I. Children & Allergies. [cited 2018 22 February]; Available from: http://acaai.org/allergies/who-has-allergies/children-allergies (accessed 8 May 2019).
176 Patient.co.uk Professional Reference. Allergic Rhinitis. [cited 2018 22 February]; Available from: https://patient.info/doctor/allergic-rhinitis-pro (accessed 8 May 2019).
177 WebMD. Best and Worst Flowers for People With Allergies. [cited 2018 22 February]; Available from: https://www.webmd.com/allergies/best-worst-plants (accessed 8 May 2019).
178 NICE Clinical Knowledge Summaries. Sinusitis. Causes. [cited 2018 22 February]; Available from: https://cks.nice.org.uk/sinusitis#!backgroundsub:1 (accessed 8 May 2019).
179 Medscape. Acute Sinusitis Clinical Presentation. [cited 2018 22 February]; Available from: https://emedicine.medscape.com/article/232670-clinical#showall (accessed 8 May 2019).
180 Bollen CML Beikler T, Halitosis: the multidisciplinary approach. Int J Oral Sci, 2012. 4(2): p. 55-63.
181 Patient.co.uk Professional Reference. Sinusitis [cited 2018 22 February]; Available from: https://patient.info/doctor/sinusitis-pro (accessed 8 May 2019).
182 Medscape. Allergic Fungal Sinusitis Treatment & Management. [cited 2018 22 February]; Available from: https://emedicine.medscape.com/article/834401-treatment#showall (accessed 8 May 2019).
183 Respiratory system, drug delivery. British National Formulary. Available from https://bnf.nice.org.uk/treatment-summary/respiratory-system-drug-delivery.html (accessed 10 July 2018)
184 Otrivine Adult Nasal Spray. Emc. Available from
https://www.medicines.org.uk/emc/product/6155/smpc (accessed 10 July 2018) 
185 Pseudoephedrine (Professional Patient Advice). Drugs.com. Available from
https://www.drugs.com/ppa/pseudoephedrine.html (accessed 10 July 2018) 
186 Otrivine Adult Nasal Spray. Emc. SmPC. Available from
https://www.medicines.org.uk/emc/product/6155/smp (accessed 10 July 2018) 
187 Otrivine Adult Nasal Spray. Emc. Patient Leaflet. Available from
https://www.medicines.org.uk/emc/files/pil.6155.pdf (accessed 10 July 2018) 
188 Common cold - Management. NICE CKS. Available from
https://cks.nice.org.uk/common-cold#!scenario (accessed 10 July 2018) 
189 Upper Respiratory Tract Infection Treatment & Management. Medscape. Available from
https://emedicine.medscape.com/article/302460-treatment#showall (accessed 10 July 2018)
190 Sinusitis. Patient.co.uk Professional Reference. Avaliable from
https://patient.info/doctor/sinusitis-pro (accessed 10 July 2018) 
191 Global Labeling. 2013. Otrivin. Regular (F.2), Moisturising (F.5), Preservative-Free (F.3), Menthol (F.4), Menthol Preservative-Free (F.6) CDS.
192 Health Care Guideline Diagnosis and Treatment of Respiratory Illness in Children and Adults. ICSI. Available from
https://www.icsi.org/_asset/pwyrky/RespIllness.pdf (accessed 10 July 2018) 
193 Common cold. NICE CKS. Available from
https://cks.nice.org.uk/common-cold#!diagnosissub (accessed 10 July 2018)
194 Connell JT, Linzmayer M. Am. J. Rhinology 1987;1:87–94.